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Barone 2013

Created By: James Mosley
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Dear James,

I'm glad to hear that you are interested in glucose detection and our work.

A couple of items before I answer your questions. First, I worked on this project while in Professor Michael Strano's lab at MIT. I have since moved on from his lab and am no longer working in this field. His lab is continuing to work on glucose detection but I am not involved in that work. Second, the glucose sensing tattoo was an idea for how our novel sensor technology could be employed but we have not yet created a working tattoo with our sensor technology.

Now to answer your questions:
1.) How is the sensor able to monitor glucose?
-- When light (we planned on on using something similar to a laser pointer) is shone on the tattoo ink the ink glows (it is not visible to human eyes though). [1]How bright the ink glows depends on the amount of glucose that is in the body. So for the device to be useful as a glucose monitor, there are two components that are needed. The first component is the tattoo itself. The second component is a monitor that would shine light on the tattoo and measure how bright the tattoo was. We envisioned that this would be a watch-like device that could easily be positioned over the tattoo.

2.) How is the sensor more accurate?
-- Current continuous glucose monitors require that the patient uses a finger-prick test to calibrate the sensor or verify that the sensor signal (usually electrical signal) is equal to a specific amount of glucose in the body. For these monitors the signal "drifts" over time and patients must [2]re-calibrate their monitor at least once per day for as long as they use the device (which can typically only be for 7 days). Because of how our sensor is designed there is no signal "drift", and this calibration step is not necessary. [3]So our device is more accurate because the signal will not "drift" and change over the lifetime of the device. A specific signal will always indicate a specific amount of glucose.

Hope these answers help.

Best regards,
Paul

On Apr 12, 2013, at 7:55 PM, James Mosley wrote:

Dear Dr. Barone,
My name is James Mosley. I am a freshman at Santiago High School in Corona, California. I am currently working on a research paper on glucose monitoring tattoos. I read an article from MIT that said that you were working on a new glucose monitor that didn’t need finger pricks and was more accurate. I was wondering how it was able to monitor glucose through the skin, and how it was more accurate.
Thank You,
James Mosley

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